Wide therapeutic expertise

with over 1100 studies conducted

Therapeutic Areas

and related breakdown

Oncology

42% of all OPIS studies conducted between 2007 and 2015 were in Oncology and Onco-hematology.

oncology Created with Sketch. 5% Melanoma 20% Breast Cancers 10% Lung Cancers 12% Gastrointestinal / Liver / Pancreatic Cancers 22% Others 23% Blood Cancers 8% Genitourinary / Renal Cancers

Hematology

Onco-Hematology indications include Leukemia, Lymphoma, Myeloma and Myelofibrosis.

Hematology indications include Anemia, Mastocytosis, Thalassemia, Drepanocytosis, Hemophilia, Hypereosinophilic syndrome, Idiopathic thrombocytopenic purpura, Polycythemia vera, Aplasia, Hemosiderosis and Von Willebrand disease.

ematology Created with Sketch. 70% Onco-Hematology 29,2% Hematology

Cardiovascular Diseases

cardiopathy Created with Sketch. 7,9% Venous Diseases 17,5% Coronary Diseases 41,3% Hypertension 33,3% Heart Failure

Neurology

47 % of studies conducted between 2007 and 2015 were in Multiple Sclerosis and other indications include Parkinson’s disease, Alzheimer’s disease, Vascular dementia, Acute demyelinating optic neuritis and Epilepsy.

neurology Created with Sketch. 22% Phase IV 46% Early Phase 15% Observation 17% Phase III

Pulmonary / Respiratory Diseases

Indications include Pulmonary arterial hypertension, Lymphangioleiomyomatosis, IPF, Chronic obstructive pulmonary disease and Asthma.

pulmonary Created with Sketch. 15,5% Pulmonary Arterial Hypertension 8,6% Idiopathic Pulmonary Fibrosis 1,7% Lymphangioleiomyomatosis 29,3% Asthma 44,8% Chronic Obstructive Pulmonary Disease

Rheumatology

Indications include Psoriaticarthritis, Juvenile idiopathic arthritis, Rheumatoid arthritis, Spondylo arthritis and
Polymyalgia rheumatica.

rheumatology Created with Sketch. 2,1% Polymyalgia Rheumatica 10,6% Psoriatic Arthritis 10,6% Spondyloarthritis 48,9% Rheumatoid Arthritis 27,7% Juvenile Idiopathic Arthritis

Immunology

Organ transplant studies included heart, liver and kidney transplants.

immunology Created with Sketch. 16% Phase IV 2% Med Devices 23% Early Phase 59% Phase III

Metabolism and Nutritional Disorders

Main experience in Diabetes studies. More than 80% of studies conducted in Diabetes. Other indications include Metabolic syndrome, Mixed dyslipidemia and Obesity.

metabolism Created with Sketch. 87,8% Diabetes 12,2% Other

Ophthalmology

OCCHIO Created with Sketch. Indications include: Age-related macular degeneration Bilateral cataracts Choroidal neovascularization Diabetic macular edema Diabetic retinopathy Dry eye Geographic Atrophy Glaucoma/Ocular hypertension Macular edema Panuveitisin Behçet's disease Posterior capsule opacity Retinitis pigmentosa Retinopathy of prematurity

Trial Distribution

2007-2015 / Experience based on more than 1000 trials

trial distribution Created with Sketch. 29,8% Oncology 14,2% Hematology 6,3% Cardiovascular diseases 6,1% Neurology 4,8% Rheumatology 4,7% Immunology 3,9% Ophthalmology 11% Phase I 30% Phase II 43% Phase III 7% Phase IV 7% Observational 2% Med Devices

Other Areas of Expertise

In addition to our experience in main pharmaceutical therapeutic areas, we have also conducted a number of clinical trials in other areas, including:

Infections and infectious diseases

Genetic Disease

Gastroenterology

Dermatology

Endocrinology

Musculoskeletal

Psychiatry/Psychology

Vaccines

Nephrology

Urology

Healthy volunteers

Gynecology

Dental and oral health

Diagnostics

Medical devices